Most of the changes to create the 2006 Cadillac DTS are cosmetic. From the windshield pillars forward, the DTS is redesigned with a new power-bulge hood, egg-crate grille, trapezoidal bi-xenon headlights, bumper fascia, and fenders. The doors and greenhouse are carried over from the current DeVille, but the multi-spoke wheels are new. In back, the revised quarter panels, LED tail lamps, decklid, and bumper update the appearance of the DTS, though we see more than a hint of vintage Chevy Monte Carlo in the rear styling. The new look brings the DTS into line with the CTS and STS to create a familial resemblance.

More important is the new interior design, which resolves the weaknesses of the DeVille. Simpler and more elegant than before, the improved cabin of the 2006 Cadillac DTS is instantly apparent to those familiar with the DeVille. The front seats have been redesigned for improved comfort, the parts fit together better and with flush seams, and the control layout is easier to use and understand than before. A front bench seat is still available, allowing the DTS to carry six adults.