A recent development in the pickup Truck segment is the emergence of the six-cylinder engine as a powerhouse. Sure, compact pickups have run them for years—those are the ‘big” engines in that class. But when you’re talking 1500-series trucks, most six-cylinder engines weren’t taken seriously at all. This is now history. As a result, this list of the best six-cylinder trucks contains some of the most noted models in the category. Advances in turbocharging, direct fuel injection, and variable valve timing have made extracting 300+ horsepower from a V6 engine pretty much routine. Further, these remarkable power increases come with strong fuel economy and smaller emissions footprints too.